Composer Peter Bretter (Jason Segel) is in a five-year relationship with actress Sarah Marshall (Kristen Bell), who stars in a ''CSI: Crime Scene Investigation''-like television show titled ''Crime Scene: Scene of the Crime''. One day, as Peter stands stark naked in their apartment, Sarah announces that she is breaking up with him. Devastated, and unable to banish his grief through one-night stands, Peter takes a trip to Hawaii. However, the vacation is ruined when he learns that Sarah and her new rock star boyfriend Aldous Snow (Russell Brand) are also guests of the resort. Taking pity on him, hotel concierge Rachel (Mila Kunis) offers him an expensive suite for free in exchange for cleaning up the room himself.

Competition between the maid of honor and a bridesmaid, over who is the bride's best friend, threatens to upend the life of an out-of-work pastry chef.

Mikey Saber is a washed-up porn star who returns to his small Texas hometown, not that anyone really wants him back.

In a magically realistic version of Toronto, a young man must defeat his new girlfriend's seven evil exes one by one in order to win her heart.